Direct flights from Knoxville
38 nonstop destinations. Zero layovers, zero connections — just one hop out of TYS.
Usually: Jacksonville (JAX), on Allegiant
Las Vegas (LAS), 1,750 miles · 3 h 50 m
Where one hop gets you
Dashed arcs = nonstop routes from TYS · updates with the day filterDrag to pan · scroll with ⌘/Ctrl to zoom · arrow keys when focused
Hotels near TYS with a free airport shuttle 13% of flights from TYS leave before 7am
Airline schedules filed for the week of Jan 4–Jan 10 show these changes from TYS:
- Allegiant to Newark (EWR) — down to 2 a week, from 4 now
- Allegiant to Las Vegas (LAS) — down to 2 a week, from 4 now
- Allegiant to Phoenix (PHX) — down to 2 a week, from 5 now
- Allegiant to Boston (BOS) — none scheduled that week; 6 a week now
- Allegiant to Denver (DEN) — none scheduled that week; 2 a week now
Show 6 more changes
- Allegiant to Houston Hobby (HOU) — none scheduled that week; 2 a week now
- Avelo Airlines to New Haven (HVN) — none scheduled that week; 2 a week now
- Allegiant to Washington Dulles (IAD) — none scheduled that week; 2 a week now
- Allegiant to Jacksonville (JAX) — none scheduled that week; 2 a week now
- Allegiant to Chicago Midway (MDW) — none scheduled that week; 2 a week now
- Allegiant to Destin-Fort Walton Beach (VPS) — none scheduled that week; 4 a week now
From schedules as filed on Nov 1. Airlines change them, so confirm before you book. We check Allegiant, Breeze, Avelo and Sun Country once a month — the airlines whose routes come and go with the seasons.
American
United
Delta
Allegiant
SouthwestFlight numbers from Knoxville (TYS)
Each one's timetable, usual aircraft and how it ran in our sample.
What changed in the past year
Comparing August 2025 with November 2026 · TYS
- American stopped flying to Atlanta.
- Frontier stopped flying to Denver.
- Allegiant stopped flying to Minneapolis.
- Nonstop service to Nashville began, now 14 flights a week.
- Nonstop service to Baltimore began, now 8 flights a week.
- Nonstop service to Dallas began, now 7 flights a week.
- Southwest started flying to Denver.
- United started flying to Newark.
…and 15 smaller changes over the same period.
- Airports near Gatlinburg 28 mi
- Airports near Asheville 82 mi
Parking rates & lots at McGhee Tyson Airport official airport site · flyknoxville.com
Where can you fly nonstop from Knoxville (TYS)?
McGhee Tyson Airport (TYS) offers nonstop flights to 38 destinations across the United States. The busiest direct routes from TYS are served by American, Allegiant, United and Delta, with the most frequent nonstop service to Charlotte, Chicago and Atlanta.
Every route below leaves TYS and lands at your destination — no layovers, no connections. Use the day filter above to see exactly which routes fly on the day you want to travel. Route data updated November 2026 from observed departures.
Usually the cheapest nonstop from Knoxville is to Jacksonville (JAX) on Allegiant, then Orlando (MCO) on Allegiant, then Punta Gorda (PGD) on Allegiant.
Longest nonstop from Knoxville: Las Vegas (LAS), about 1,750 miles and 3 h 50 m.
Airlines and flight times at TYS
6 airlines fly nonstop out of TYS. American runs the biggest operation — about 182 of the 503 weekly departures (36%), across 6 routes — followed by United and Delta.
The airlines flying nonstop out of Knoxville are American, United, Delta, Allegiant, Southwest and Avelo Airlines.
On 29 of Knoxville's 38 nonstop routes, a single airline has the service to itself — American is the only airline with a nonstop to Charlotte, and Delta the only one to Atlanta.
The shortest nonstop out of TYS is Charlotte at about 31m in the air; the longest is Phoenix at about 3h58m.
Route data updated November 2026 from observed flight departures. Schedules change — always confirm with the airline before booking.