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American · McGhee Tyson Airport · TYS

American nonstop flights from Knoxville

6 nonstop destinations on American out of TYS — 36% of everything that departs. Zero layovers, zero connections.

6
Nonstop cities
36%
of TYS departures
182
Flights / week
TYS
Your origin

Where American can take you

Dashed arcs = American nonstop routes from TYS · updates with the day filter
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All nonstop destinations from Knoxville (TYS) every airline, not just American

Everywhere American flies 346 airports

American flight numbers from Knoxville (TYS)

Each one's timetable, usual aircraft and how it ran in our sample.

AA2836 to Dallas-Fort Worth AA2498 to Dallas-Fort Worth AA1325 to Miami All 2,053 American flight numbers →

Where can you fly nonstop on American from Knoxville (TYS)?

American flies 6 nonstop routes from McGhee Tyson Airport (TYS), around 182 departures a week — 36% of everything leaving TYS.

Its busiest is Knoxville to Charlotte at 59 American flights a week. 4 of these 6 destinations have no other nonstop operator from TYS, so American is the only way to reach them without a connection.

Use the day filter above to see which American routes fly on the day you want to travel. Route data updated November 2026 from observed departures.

Frequencies shown are American's own departures, counted from observed schedules. Schedules change — always confirm with the airline before booking.