Direct flights from Minneapolis to Knoxville
13 nonstop flights a week on 1 airline. Zero layovers — one hop from MSP to TYS.
Flight time: about 1h44m nonstop
Which days does it fly?
When does it fly?
Departure times in Minneapolis local time, from flights observed over the last 7 days.
| Flight | Departs | Duration | Days |
|---|---|---|---|
| Delta EDV5335 | 1:40p | 1h38m | Mon, Wed |
| Delta EDV5335 | 1:49p | 1h42m | Tue, Thu, Sun |
| Delta EDV5335 | 3:22p | 1h47m | Fri |
| Delta EDV5527 | 8:10p | 1h34m | Mon, Sat |
| Delta EDV5527 | 8:16p | 1h53m | Tue, Sun |
| Delta EDV5527 | 8:29p | 1h58m | Fri |
| Delta EDV5527 | 8:38p | 1h45m | Thu |
| Delta EDV5527 | 8:54p | 1h40m | Wed |
Delta
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The route
One hop: MSP → TYSDrag to pan · scroll with ⌘/Ctrl to zoom · arrow keys when focused
Nonstop from Minneapolis (MSP) to Knoxville (TYS)
Minneapolis–Saint Paul International Airport / Wold–Chamberlain Field (MSP) has 13 nonstop flights a week to Knoxville (TYS), operated by Delta. No layovers, no connections — one hop out of MSP and you're there.
This route flies every day of the week, so any travel day works. Route data updated October 2026 from observed departures.
Route data updated October 2026 from observed flight departures. Schedules change — always confirm with the airline before booking.
How long is the flight from Minneapolis to Knoxville?
The nonstop flight from Minneapolis (MSP) to Knoxville (TYS) takes about 1h44m in the air, based on recently observed nonstop departures.
How long does it take to drive from Minneapolis to Knoxville?
Driving from Minneapolis to Knoxville takes about 13h 57m, covering roughly 948 miles. The nonstop flight takes about 1h44m.