Direct flights from Knoxville to St Louis
1 nonstop flight a week on 1 airline. Zero layovers — one hop from TYS to STL.
Flight time: about 1h3m nonstop
Which days does it fly?
When does it fly?
Departure times in Knoxville local time, from flights observed over the last 7 days.
| Flight | Departs | Duration | Days |
|---|---|---|---|
| Southwest SWA8506 | 9:49a | 1h3m | Sat |
Southwest
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The route
One hop: TYS → STLDrag to pan · scroll with ⌘/Ctrl to zoom · arrow keys when focused
Nonstop from Knoxville (TYS) to St Louis (STL)
McGhee Tyson Airport (TYS) has 1 nonstop flight a week to St Louis (STL), operated by Southwest. No layovers, no connections — one hop out of TYS and you're there.
This route flies on Saturday — check the schedule grid above before you pick a travel day. Route data updated August 2026 from observed departures.
Route data updated August 2026 from observed flight departures. Schedules change — always confirm with the airline before booking.
How long is the flight from Knoxville to St Louis?
The nonstop flight from Knoxville (TYS) to St Louis (STL) takes about 1h3m in the air, based on recently observed nonstop departures.