Direct flights from Knoxville to Lexington
1 nonstop flight a week on 1 airline. Zero layovers — one hop from TYS to LEX.
Flight time: about 30m nonstop
Which days does it fly?
When does it fly?
Departure times in Knoxville local time, from flights observed over the last 7 days.
| Flight | Departs | Duration | Days |
|---|---|---|---|
| American ENY3621 | 6:05p | 30m | Tue |
American
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The route
One hop: TYS → LEXDrag to pan · scroll with ⌘/Ctrl to zoom · arrow keys when focused
Nonstop from Knoxville (TYS) to Lexington (LEX)
McGhee Tyson Airport (TYS) has 1 nonstop flight a week to Lexington (LEX), operated by American. No layovers, no connections — one hop out of TYS and you're there.
This route flies on Tuesday — check the schedule grid above before you pick a travel day. Route data updated July 2026 from observed departures.
Route data updated July 2026 from observed flight departures. Schedules change — always confirm with the airline before booking.
How long is the flight from Knoxville to Lexington?
The nonstop flight from Knoxville (TYS) to Lexington (LEX) takes about 30m in the air, based on recently observed nonstop departures.
How long does it take to drive from Knoxville to Lexington?
Driving from Knoxville to Lexington takes about 2h 45m — roughly 173 miles — so the car is a real alternative on this route. The nonstop flight takes about 30m.