Direct flights from Knoxville to Houston
23 nonstop flights a week on 2 airlines. Zero layovers — one hop from TYS to IAH.
Flight time: about 1h46m nonstop
Which days does it fly?
When does it fly?
Departure times in Knoxville local time, from flights observed over the last 7 days.
| Flight | Departs | Duration | Days |
|---|---|---|---|
| Mesa ASH6298 | 7:18a | 1h45m | Mon, Fri, Sat |
| Mesa ASH6298 | 7:26a | 1h52m | Wed, Sun |
| Mesa ASH6298 | 7:39a | 1h47m | Thu |
| Mesa ASH6298 | 10:57a | 1h45m | Tue |
| United UCA3262 | 11:12a | 1h39m | Mon |
| Mesa ASH6299 | 12:14p | 1h45m | Thu–Fri |
| Mesa ASH3237 | 12:20p | 1h52m | Wed |
| Mesa ASH6299 | 12:20p | 1h46m | Mon, Tue, Wed, Sat |
| United UCA4843 | 12:30p | 1h59m | Sun |
| Mesa ASH4046 | 3:33p | 1h47m | Fri–Sun |
| Mesa ASH4046 | 3:35p | 1h45m | Mon |
| Mesa ASH4046 | 3:51p | 1h46m | Tue |
| Mesa ASH4046 | 4:21p | 1h51m | Wed–Thu |
UnitedThe route
One hop: TYS → IAHDrag to pan · scroll with ⌘/Ctrl to zoom · arrow keys when focused
Nonstop from Knoxville (TYS) to Houston (IAH)
McGhee Tyson Airport (TYS) has 23 nonstop flights a week to Houston (IAH), operated by Mesa and United. No layovers, no connections — one hop out of TYS and you're there.
This route flies every day of the week, so any travel day works. Route data updated July 2026 from observed departures.
Route data updated July 2026 from observed flight departures. Schedules change — always confirm with the airline before booking.
How long is the flight from Knoxville to Houston?
The nonstop flight from Knoxville (TYS) to Houston (IAH) takes about 1h46m in the air, based on recently observed nonstop departures.
How long does it take to drive from Knoxville to Houston?
Driving from Knoxville to Houston takes about 13h 28m, covering roughly 926 miles. The nonstop flight takes about 1h46m.