Direct flights from Knoxville to Chicago
53 nonstop flights a week on 4 airlines. Zero layovers — one hop from TYS to ORD.
Flight time: about 1h20m nonstop
Which days does it fly?
When does it fly?
Departure times in Knoxville local time, from flights observed over the last 7 days.
| Flight | Departs | Duration | Days |
|---|---|---|---|
| United UAL2483 | 6:08a | 1h20m | Mon, Tue, Thu, Fri, Sat, Sun |
| SkyWest SKW6216 | 6:46a | 1h30m | Sat |
| SkyWest SKW6216 | 7:13a | 1h20m | Mon |
| SkyWest SKW6216 | 7:15a | 1h20m | Wed–Fri |
| SkyWest SKW6216 | 7:26a | 1h34m | Tue, Sun |
| GoJet GJS4584 | 10:23a | 1h22m | Wed, Sun |
| GoJet GJS4584 | 10:26a | 1h36m | Tue, Thu |
| GoJet GJS4584 | 10:43a | 1h20m | Mon, Fri |
| SkyWest SKW6445 | 11:40a | 1h16m | Fri, Sun |
| SkyWest SKW6445 | 11:50a | 1h16m | Tue–Thu |
| GoJet GJS4584 | 12:01p | 1h20m | Sat |
| SkyWest SKW6445 | 12:26p | 1h12m | Mon |
| SkyWest SKW5014 | 1:14p | 1h9m | Wed |
| SkyWest SKW5014 | 1:15p | 1h9m | Tue |
| SkyWest SKW5014 | 1:31p | 1h9m | Thu |
| SkyWest SKW5014 | 1:35p | 1h15m | Fri |
| SkyWest SKW5014 | 1:52p | 1h18m | Mon, Sat |
| SkyWest SKW5617 | 2:11p | 1h20m | Tue, Wed, Thu, Sun |
| SkyWest SKW5014 | 2:11p | 1h15m | Sun |
| SkyWest SKW5617 | 2:16p | 1h20m | Mon |
| SkyWest SKW5617 | 2:33p | 1h38m | Sat |
| SkyWest SKW6000 | 5:52p | 1h20m | Tue |
| SkyWest SKW6000 | 6:02p | 1h20m | Mon, Wed, Thu, Sun |
| American ENY3783 | 6:42p | 1h24m | Sun |
| SkyWest SKW6000 | 6:42p | 1h20m | Fri |
| American ENY3783 | 6:45p | 1h21m | Mon |
| American ENY3783 | 7:23p | 1h20m | Tue–Thu |
| SkyWest SKW6000 | 8:06p | 1h20m | Sat |
| American ENY3783 | 8:09p | 1h29m | Sat |
| American ENY3783 | 8:39p | 1h19m | Fri |
American
UnitedThe route
One hop: TYS → ORDDrag to pan · scroll with ⌘/Ctrl to zoom · arrow keys when focused
Nonstop from Knoxville (TYS) to Chicago (ORD)
McGhee Tyson Airport (TYS) has 53 nonstop flights a week to Chicago (ORD), operated by American, GoJet, SkyWest and United. No layovers, no connections — one hop out of TYS and you're there.
This route flies every day of the week, so any travel day works. Route data updated July 2026 from observed departures.
Route data updated July 2026 from observed flight departures. Schedules change — always confirm with the airline before booking.
How long is the flight from Knoxville to Chicago?
The nonstop flight from Knoxville (TYS) to Chicago (ORD) takes about 1h20m in the air, based on recently observed nonstop departures.
How long does it take to drive from Knoxville to Chicago?
Driving from Knoxville to Chicago takes about 8h 9m, covering roughly 541 miles. The nonstop flight takes about 1h20m.