Direct flights from Des Moines to Chicago
14 nonstop flights a week on 1 airline. Zero layovers — one hop from DSM to MDW.
Flight time: about 54m nonstop
Which days does it fly?
When does it fly?
Departure times in Des Moines local time, from flights observed over the last 7 days.
| Flight | Departs | Duration | Days |
|---|---|---|---|
| Southwest SWA463 | 5:16a | 56m | Sat |
| Southwest SWA1558 | 5:20a | 52m | Sun |
| Southwest SWA1772 | 5:20a | 56m | Mon–Fri |
| Southwest SWA1524 | 4:26p | 56m | Sat |
| Southwest SWA1524 | 4:42p | 50m | Sun |
| Southwest SWA1755 | 4:45p | 51m | Thu |
| Southwest SWA1524 | 4:45p | 54m | Tue–Wed |
| Southwest SWA1755 | 4:56p | 1h | Fri |
| Southwest SWA1755 | 5:16p | 51m | Mon |
Southwest
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The route
One hop: DSM → MDWDrag to pan · scroll with ⌘/Ctrl to zoom · arrow keys when focused
Nonstop from Des Moines (DSM) to Chicago (MDW)
Des Moines International Airport (DSM) has 14 nonstop flights a week to Chicago (MDW), operated by Southwest. No layovers, no connections — one hop out of DSM and you're there.
This route flies every day of the week, so any travel day works. Route data updated July 2026 from observed departures.
Route data updated July 2026 from observed flight departures. Schedules change — always confirm with the airline before booking.
How long is the flight from Des Moines to Chicago?
The nonstop flight from Des Moines (DSM) to Chicago (MDW) takes about 54m in the air, based on recently observed nonstop departures.
How long does it take to drive from Des Moines to Chicago?
Driving from Des Moines to Chicago takes about 4h 58m, covering roughly 334 miles. The nonstop flight takes about 54m.