Direct flights from Des Moines to Chicago
68 nonstop flights a week on 4 airlines. Zero layovers — one hop from DSM to ORD.
Flight time: about 56m nonstop
Which days does it fly?
When does it fly?
Departure times in Des Moines local time, from flights observed over the last 7 days.
| Flight | Departs | Duration | Days |
|---|---|---|---|
| Republic Airways RPA4519 | 5:13a | 1h | Mon, Tue, Thu |
| Republic Airways RPA4519 | 5:15a | 1h | Sun |
| Republic Airways RPA4519 | 5:43a | 1h | Wed |
| United UAL1856 | 6:02a | 1h | Mon, Wed |
| United UAL1856 | 6:08a | 54m | Thu–Fri |
| United UAL1856 | 6:16a | 58m | Tue, Sat |
| Republic Airways RPA4519 | 6:40a | 48m | Fri |
| United UAL2287 | 7:47a | 56m | Mon, Thu |
| United UAL2287 | 8:01a | 59m | Wed |
| United UAL2287 | 8:12a | 54m | Tue, Fri, Sun |
| SkyWest SKW4969 | 8:48a | 1h2m | Mon, Sat |
| United UAL2287 | 8:52a | 54m | Sat |
| SkyWest SKW4969 | 9:00a | 54m | Wed–Fri |
| SkyWest SKW4969 | 9:12a | 56m | Tue, Sun |
| United UAL1410 | 11:24a | 53m | Mon, Wed |
| United UAL1410 | 11:26a | 53m | Tue |
| United UAL1410 | 11:37a | 56m | Sun |
| United UAL1410 | 11:55a | 55m | Thu |
| United UAL1856 | 12:17p | 50m | Sun |
| United UAL1410 | 12:38p | 53m | Sat |
| Republic Airways RPA4676 | 1:48p | 56m | Mon, Tue, Wed, Sun |
| Republic Airways RPA4676 | 2:00p | 59m | Thu |
| Republic Airways RPA4676 | 2:32p | 28m | Sat |
| Republic Airways RPA9932 | 2:35p | 51m | Sat |
| United UAL1989 | 3:46p | 55m | Mon, Tue, Wed, Thu, Sun |
| Republic Airways RPA4676 | 3:51p | 59m | Fri |
| SkyWest SKW4973 | 6:22p | 50m | Sat |
| United UAL1989 | 6:36p | 59m | Fri |
| SkyWest SKW4973 | 6:45p | 1h5m | Wed |
| SkyWest SKW6050 | 6:58p | 58m | Tue, Wed, Sun |
| SkyWest SKW6050 | 7:11p | 58m | Mon, Sat |
| SkyWest SKW4973 | 7:17p | 1h5m | Mon, Tue, Sun |
| SkyWest SKW6050 | 7:34p | 53m | Thu |
| SkyWest SKW4973 | 7:55p | 50m | Fri |
| SkyWest SKW6050 | 8:06p | 58m | Fri |
| SkyWest SKW4973 | 8:36p | 1h7m | Thu |
| American ENY4102 | 8:50p | 56m | Tue, Sat |
| American ENY4102 | 9:00p | 57m | Mon, Sun |
| American ENY4102 | 9:16p | 56m | Thu |
| American ENY4102 | 9:36p | 1h21m | Wed |
| American ENY4102 | 10:40p | 53m | Fri |
American
UnitedThe route
One hop: DSM → ORDDrag to pan · scroll with ⌘/Ctrl to zoom · arrow keys when focused
Nonstop from Des Moines (DSM) to Chicago (ORD)
Des Moines International Airport (DSM) has 68 nonstop flights a week to Chicago (ORD), operated by American, Republic Airways, SkyWest and United. No layovers, no connections — one hop out of DSM and you're there.
This route flies every day of the week, so any travel day works. Route data updated July 2026 from observed departures.
Route data updated July 2026 from observed flight departures. Schedules change — always confirm with the airline before booking.
How long is the flight from Des Moines to Chicago?
The nonstop flight from Des Moines (DSM) to Chicago (ORD) takes about 56m in the air, based on recently observed nonstop departures.
How long does it take to drive from Des Moines to Chicago?
Driving from Des Moines to Chicago takes about 4h 58m, covering roughly 334 miles. The nonstop flight takes about 56m.