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American · Cleveland Hopkins International Airport · CLE

American nonstop flights from Cleveland

10 nonstop destinations on American out of CLE — 25% of everything that departs. Zero layovers, zero connections.

10
Nonstop cities
25%
of CLE departures
230
Flights / week
CLE
Your origin

Where American can take you

Dashed arcs = American nonstop routes from CLE · updates with the day filter
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All nonstop destinations from Cleveland (CLE) every airline, not just American

Everywhere American flies 346 airports

American flight numbers from Cleveland (CLE)

Each one's timetable, usual aircraft and how it ran in our sample — 12 of the 14 we cover from CLE, flown most days first.

Where can you fly nonstop on American from Cleveland (CLE)?

American flies 10 nonstop routes from Cleveland Hopkins International Airport (CLE), around 230 departures a week — 25% of everything leaving CLE.

Its busiest is Cleveland to Chicago at 42 American flights a week. 3 of these 10 destinations have no other nonstop operator from CLE, so American is the only way to reach them without a connection.

Use the day filter above to see which American routes fly on the day you want to travel. Route data updated November 2026 from observed departures.

Frequencies shown are American's own departures, counted from observed schedules. Schedules change — always confirm with the airline before booking.