Direct flights from Chicago to Knoxville
56 nonstop flights a week on 2 airlines. Zero layovers — one hop from ORD to TYS.
Flight time: about 1h10m nonstop
Which days does it fly?
When does it fly?
Departure times in Chicago local time, from flights observed over the last 7 days.
| Flight | Departs | Duration | Days |
|---|---|---|---|
| GoJet GJS4519 | 7:11a | 1h20m | Sun |
| GoJet GJS4519 | 7:16a | 1h20m | Mon, Tue, Fri |
| American ENY4102 | 8:09a | 1h30m | Wed |
| American ENY4102 | 8:17a | 1h8m | Fri |
| GoJet GJS4519 | 8:32a | 1h20m | Wed |
| American ENY4102 | 8:33a | 1h7m | Tue |
| American ENY4102 | 8:38a | 1h5m | Sun |
| American ENY4102 | 8:46a | 1h3m | Mon |
| American ENY4102 | 9:01a | 1h29m | Thu |
| American ENY4002 | 9:53a | 1h3m | Fri |
| American ENY4002 | 10:07a | 1h10m | Mon, Sun |
| GoJet GJS4592 | 10:36a | 1h20m | Sun |
| GoJet GJS4592 | 10:47a | 1h20m | Mon |
| GoJet GJS4592 | 11:00a | 1h7m | Fri |
| American ENY4102 | 11:57a | 1h21m | Sat |
| GoJet GJS4592 | 12:56p | 1h20m | Tue |
| American ENY4105 | 1:33p | 1h20m | Wed |
| GoJet GJS4592 | 1:36p | 1h20m | Thu |
| American ENY4105 | 1:39p | 1h6m | Mon, Sun |
| American ENY4105 | 2:11p | 1h14m | Tue, Fri |
| United UAL1244 | 2:39p | 1h4m | Sun |
| United UAL1244 | 2:50p | 1h5m | Wed |
| United UAL1244 | 3:06p | 1h6m | Tue |
| United UAL1244 | 3:20p | 1h10m | Mon, Fri |
| American ENY4105 | 3:27p | 1h4m | Thu |
| Republic Airways RPA3289 | 4:12p | 53m | Wed |
| American ENY4105 | 4:17p | 1h22m | Sat |
| SkyWest SKW6344 | 5:19p | 1h11m | Sun |
| United UAL1244 | 5:20p | 1h7m | Thu, Sat |
| SkyWest SKW6344 | 5:43p | 1h14m | Mon–Fri |
| SkyWest SKW6344 | 6:49p | 1h13m | Sat |
| American ENY3699 | 8:11p | 1h5m | Mon, Sun |
| United UAL661 | 8:22p | 1h12m | Mon, Fri |
| American ENY3699 | 8:23p | 1h8m | Sat |
| United UAL661 | 8:29p | 1h4m | Sat–Sun |
| American ENY3699 | 8:44p | 1h22m | Fri |
| United UAL661 | 8:53p | 1h4m | Wed |
| American ENY3699 | 9:00p | 1h16m | Tue–Wed |
| American ENY3699 | 10:24p | 1h6m | Thu |
| United UAL1295 | 10:54p | 1h5m | Tue |
| United UAL661 | 11:01p | 1h4m | Thu |
American
UnitedThe route
One hop: ORD → TYSDrag to pan · scroll with ⌘/Ctrl to zoom · arrow keys when focused
Nonstop from Chicago (ORD) to Knoxville (TYS)
Chicago O'Hare International Airport (ORD) has 56 nonstop flights a week to Knoxville (TYS), operated by American and United. No layovers, no connections — one hop out of ORD and you're there.
This route flies every day of the week, so any travel day works. Route data updated September 2026 from observed departures.
Route data updated September 2026 from observed flight departures. Schedules change — always confirm with the airline before booking.
How long is the flight from Chicago to Knoxville?
The nonstop flight from Chicago (ORD) to Knoxville (TYS) takes about 1h10m in the air, based on recently observed nonstop departures.
How long does it take to drive from Chicago to Knoxville?
Driving from Chicago to Knoxville takes about 8h 9m, covering roughly 541 miles. The nonstop flight takes about 1h10m.