Direct flights from Myrtle Beach to Knoxville
1 nonstop flight a week on 1 airline. Zero layovers — one hop from MYR to TYS.
Flight time: about 53m nonstop
Which days does it fly?
When does it fly?
Departure times in Myrtle Beach local time, from flights observed over the last 7 days.
| Flight | Departs | Duration | Days |
|---|---|---|---|
| Southwest SWA8800 | 6:03a | 53m | Wed |
Southwest
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The route
One hop: MYR → TYSDrag to pan · scroll with ⌘/Ctrl to zoom · arrow keys when focused
Nonstop from Myrtle Beach (MYR) to Knoxville (TYS)
Myrtle Beach International Airport (MYR) has 1 nonstop flight a week to Knoxville (TYS), operated by Southwest. No layovers, no connections — one hop out of MYR and you're there.
This route flies on Wednesday — check the schedule grid above before you pick a travel day. Route data updated July 2026 from observed departures.
Route data updated July 2026 from observed flight departures. Schedules change — always confirm with the airline before booking.
How long is the flight from Myrtle Beach to Knoxville?
The nonstop flight from Myrtle Beach (MYR) to Knoxville (TYS) takes about 53m in the air, based on recently observed nonstop departures.
How long does it take to drive from Myrtle Beach to Knoxville?
Driving from Myrtle Beach to Knoxville takes about 6h 42m, covering roughly 411 miles. The nonstop flight takes about 53m.