Direct flights from Louisville to Knoxville
1 nonstop flight a week on 1 airline. Zero layovers — one hop from SDF to TYS.
Flight time: about 53m nonstop
Which days does it fly?
When does it fly?
Departure times in Louisville local time, from flights observed over the last 7 days.
| Flight | Departs | Duration | Days |
|---|---|---|---|
| Delta DAL3195 | 4:56p | 53m | Thu |
Delta
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The route
One hop: SDF → TYSDrag to pan · scroll with ⌘/Ctrl to zoom · arrow keys when focused
Nonstop from Louisville (SDF) to Knoxville (TYS)
Louisville Muhammad Ali International Airport (SDF) has 1 nonstop flight a week to Knoxville (TYS), operated by Delta. No layovers, no connections — one hop out of SDF and you're there.
This route flies on Thursday — check the schedule grid above before you pick a travel day. Route data updated July 2026 from observed departures.
Route data updated July 2026 from observed flight departures. Schedules change — always confirm with the airline before booking.
How long is the flight from Louisville to Knoxville?
The nonstop flight from Louisville (SDF) to Knoxville (TYS) takes about 53m in the air, based on recently observed nonstop departures.
How long does it take to drive from Louisville to Knoxville?
Driving from Louisville to Knoxville takes about 3h 42m — roughly 247 miles — so the car is a real alternative on this route. The nonstop flight takes about 53m.