Louisville Muhammad Ali International Airport · SDF → BUF
Direct flights from Louisville to Buffalo
1 nonstop flight a week on 1 airline. Zero layovers — one hop from SDF to BUF.
Which days does it fly?
Republic Airways
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The route
One hop: SDF → BUFDrag to pan · scroll with ⌘/Ctrl to zoom · arrow keys when focused
Nonstop from Louisville (SDF) to Buffalo (BUF)
Louisville Muhammad Ali International Airport (SDF) has 1 nonstop flight a week to Buffalo (BUF), operated by Republic Airways. No layovers, no connections — one hop out of SDF and you're there.
This route flies on Monday — check the schedule grid above before you pick a travel day. Route data updated September 2026 from observed departures.
Route data updated September 2026 from observed flight departures. Schedules change — always confirm with the airline before booking.
How long does it take to drive from Louisville to Buffalo?
Driving from Louisville to Buffalo takes about 7h 58m, covering roughly 532 miles.