Direct flights from Buffalo to Knoxville
1 nonstop flight a week on 1 airline. Zero layovers — one hop from BUF to TYS.
Flight time: about 1h36m nonstop
Which days does it fly?
When does it fly?
Departure times in Buffalo local time, from flights observed over the last 7 days.
| Flight | Departs | Duration | Days |
|---|---|---|---|
| Delta DAL2266 | 5:24p | 1h36m | Mon |
Delta
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The route
One hop: BUF → TYSDrag to pan · scroll with ⌘/Ctrl to zoom · arrow keys when focused
Nonstop from Buffalo (BUF) to Knoxville (TYS)
Buffalo Niagara International Airport (BUF) has 1 nonstop flight a week to Knoxville (TYS), operated by Delta. No layovers, no connections — one hop out of BUF and you're there.
This route flies on Monday — check the schedule grid above before you pick a travel day. Route data updated August 2026 from observed departures.
Route data updated August 2026 from observed flight departures. Schedules change — always confirm with the airline before booking.
How long is the flight from Buffalo to Knoxville?
The nonstop flight from Buffalo (BUF) to Knoxville (TYS) takes about 1h36m in the air, based on recently observed nonstop departures.